Continuous use of morphine is known to be highly addictive. It is because of this that physicians may choose to recommend Tramadol in cases of severe and moderate pain. Pain of a continuous nature is usually controlled through regular use of painkillers. These include postoperative, back, joint and cancer-related pain. Regular uses of morphine over long periods of time to control these aches will almost always result in patient dependency on the drug.

Consuming morphine as compared to Tramadol, is known to induce histamine, which is released as a neurotransmitter. Constant histamine release may cause anxiety, agitation and restlessness. Since both these drugs can be used to combat continual pain, it is important to study side effects and patient types before medication is recommended.

Morphine is useful for controlling postoperative pain. However, in comparison to Tramadol, morphine does not have the ability to induce improved postoperative immuno-suppression. This is an important factor that makes physicians select Tramadol over morphine. Use of morphine in cases of patients being on ventilators has confirmed a depressive effect whereas Tramadol patients do not exhibit these tendencies.

In cases of chronic pancreatic pain, both Tramadol and morphine have been tested on patients. These tests are conducted to check the interaction of these medicines with gut motor function. During the observation period, side effects, bowel function, resting pressure, rectal distension and other important functions were considered. Both medicines were confirmed to reduce pain. However, it was observed that Tramadol interfered less with gastrointestinal function and at times proved to be a better pain reliever.

Both the drugs have been tested upon clinical rats and it is found to cause red neuron degeneration. This could lead to cerebral dysfunction. Irrespective of these findings more and more people are being prescribed to use Tramadol in comparison to morphine. It is important to consume this drug in its recommended dosage and only when suggested by a physician. However, people should realize that even though Tramadol is considered to be less addictive, when someone suddenly stops taking the drug, it is known to cause withdrawals.