Shox is technology developed by Nike and incorporated into several of their flagship athletic shoes. Shox are small hollow columns that make up the midsole of the shoe. They are mostly made of rubber, these being those which are actually called Shox. There are many different formations that Shox come in, but they usually come with four circular columns in a square formation for maximum cushioning. There can also be five or six Shox, 2.5 cm high, though they may vary in height, and triangular and rectangular Shox that provide better stability. Some shoes have midsoles made entirely of Shox, like the TL series.

The first shoes to use the Shox technology were introduced in late 2000, the R4 runner, the BB4 basketball shoe, and the XT4 cross-training shoe.

Nike claims that Shox not only absorb impact from heel strike while running; they also "spring back" and add more power to a runner's stride. Aside from the boost in speed, the Shox also provides superior shock absorption with high-tech elastic foam.

The newer Shox series is compatible with Nike+ technology. The Nike Shox Saya+ is the most recent Shox with this feature.

The new Nike Shox Q'Vida Hi - Women's is a new "dance boot" style of Shox.

Actor Hugh Laurie of Fox's House is said to have 37 pairs of size 12 1/2 Shox that he wears on the show and off set.

Athletes that are notable for wearing shoes with Shox technology include Vince Carter, Jermaine O'Neal, David M. West and Carlos Boozer. Some of Nike’s best selling shoes include Shox, like the Shox NZ and Shox Turbo, which are available in different colors. These shoes can be found for customization on NikeID, Nike's online shoe customizing site. There are numerous options like different colors and materials for the Shox, along with custom tags.

On February 17 2006, BBC News reported that Nike had filed a patent infringement suit against rival Adidas, claiming that a range of their trainers replicated its technology.