New Juggernaut Emerging in Depression Treatment
- Author Steven Johnson
- Published July 13, 2011
- Word count 565
People with severe depression have it rough. Depression prevents you from being proactive about your condition, doing things you know you should be to overcome the disease: exercising and eating right. And when you try medical help, drugs often do not work, do not work well, cause bad side effects (like weight gain), make the depression worse, and/or build tolerance quickly.
For this reason, nearly half of people with depression feel like they cannot find a successful medical solution.
Whenever a new drug comes out, there is always excitement - and concerns. This time, however, a well-known drug with a world-class reputation is creating a lot of buzz.
How good is this news? Find out below.
Many Depressive Conditions Do Not Respond to Treatment
SSRIs
Short for Selective Serotonin Reuptake Inhibitors, SSRIs control the amount of serotonin in your body. They have side effects like:
-
Weight gain
-
Fatigue
-
Dizziness
-
Headache
-
Nausea/Vomiting
-
Apathy
-
Drowsiness
-
Tremors
-
Suicidal thoughts
-
Sleep disruption
-
Inability to experience pleasure
-
Sexual dysfunction
Well-known SSRIs used for treatment of depression include:
-
Zoloft (sertraline)
-
Paxil (paroxetine)
-
Prozac (fluoxetine)
-
Seroplex (escitalopram)
-
Celexa (citalopram)
Tricyclic Antidepressants
These are one of the oldest classes of drug still used to treat depression. Newer drugs have largely replaced them because of fairly severe side effects, but are still used in special situations.
Common side effects include:
-
Dry mouth
-
Dry nose
-
Blurry vision
-
Constipation
-
Cognitive/Memory impairment
-
Fever
-
Confusion
-
Dizziness
-
Drowsiness
-
Anxiety
-
Emotional blunting
-
Sexual dysfunction
-
Asendin Weight gain
-
Restlessness
-
And many more!
Examples sometimes still used today are:
-
Elavil
-
Sinequan
-
Tofranil
-
Pamelor
-
Surmontil
MAOIs (Monoamine oxidase inhibitors)
When SSRIs and Tricyclic antidepressants fail, MAOIs are often called in. They are better at treating atypical depression, but are dangerous. They have bad withdrawal symptoms and very grave side effects. They are potentially lethal. Many psychiatrists will not prescribe these because of the risks. Instead, they turn to off-label treatments.
Many naturally occurring substances in the body (serotonin, norepinephrine, dopamine) and reuptake inhibitors and releasers may cause MAOIs to spike dangerously.
Why an alternative is needed
These drugs do not respond to many cases of depression. Furthermore, people often experience horrible side effects, are made worse, or develop addictions. Even when the drugs work, patients can only stay on them for so long because of the tolerance that is built, long-term harm done, and the awful withdrawal symptoms.
Sometimes doctors turn to off-label drugs.
Some examples are narcotics, Ritalin, benzodiazepines, and Tramadol.
The Promise of Tramadol
This is a popular off-label treatment already because of a wealth of evidence that it really works for many cases of depression, even the severe kind that do not respond to other treatments. There are several properties that make it an ideal drug for depression treatment, and ongoing studies are turning up positive results.
Properties:
-
Serotonin releasing agent
-
Norepinephrine reuptake inhibitor
-
NMDA receptor antagonist
-
TRPV1 receptor agonist
-
And many more
Trials
So far, trials have shown that Tramadol provides immediate relief in 100% of severe refractory depression cases. It is less addictive than other alternatives, and while you can build tolerance, you can quit for a few days and then start again anew.
Want to see what Steven Johnson has to say on other topics? With years of experience Steven Johnson is a constant writer for [http://www.tramadolbliss.com/blog/?p=32](http://www.tramadolbliss.com/blog/?p=32) and you can see all his contributions on that site.
Article source: https://articlebiz.comRate article
Article comments
There are no posted comments.
Related articles
- From Dubai Airport smugglers to Gordon Ramsay's kitchen - one of TV's top directors reveals all in our exclusive Q&A
- Red Flags to Watch for When Dating Over 40
- Why Commercial Gutter Cleaning is Essential for Your Business – And Who You Should Trust in Essex
- The Rise of Software to Monitor Employee Computer Activity: Balancing Productivity, Privacy, and Ethics
- NOSEBLEEDS, NEIGHBOURS, AND NEW YORK: HEIDI'S ARTISTIC RESURRECTION
- Top-Tier Real Estate Videography in NV: Boost Your Sales with Stunning Visuals
- Find In-Home Senior Care Services Near You in Alabama: Expert Respite, Personal, and Dementia Care Solutions
- Elevate Your Entryway with a Statement Wall: Carved Wood Panels
- What Are the Comprehensive Senior Home Care Services in Prichard, AL for Trusted Respite and Dementia Care?
- Electronic Document Management System: Efficiency and Challenges in the Digital Age
- Best Air Conditioning Repair Service Queen Creek Florence Arizona
- How to Choose an Airport Transfer Service: A Guide for Stress-Free Travel
- Wirral Private Airport Transfers: Comfort, Convenience, and Class
- North Wirral Airport Transfers by Ventus: Trusted Travel from Coast to Terminal
- The Importance of Reliable Airport Transfer Services
- Find the Perfect Fireplace for Your Home
- The Pros, Cons, and Ethical Dilemmas of Employee Computer Activity Monitoring Software
- Over 40 and Ready to Mingle? Why Now Is the Best Time to Start Dating Again
- Whu buy an apartment in Manilva
- Best Electric Humidor: Top Picks for Effortless Cigar Storage in 2025
- They Tried Magic Mushrooms for Mental Health
- Sacred Balance: 5 Elements Chakra Healing with Mala Beads & Yantras
- Rooted in Heritage: The Rich Ranch Aesthetic with Antique Doors and Rustic Soul
- Carved Floral Barn Doors: A Shabby Chic Statement for Your Pantry & Laundry Room
- Confusion and Anxiety: Lincoln and the Days Before the Civil War
- How Website Maintenance & Security Protects Your Online Presence
- 5 Best Mortgage Brokers for Bad Credit UK
- 7 Best Mortgage Brokers in Derby
- Maximising Space and Efficiency: The Power of Dual-Purpose Fitness Machines
- Types of Eco Friendly Food Packaging